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Can Alpha GPC Cause Anxiety?

Alpha GPC can cause anxiety in some individuals, but it is not common. Most people use it to improve cognitive function and physical performance.

Alpha GPC, a popular nootropic, is known for its cognitive and physical benefits. However, some users report anxiety as a side effect. This article explores the potential link between Alpha GPC and anxiety, its benefits, and other side effects.

Understanding Alpha GPC

Alpha GPC (L-alpha glycerylphosphorylcholine) is a choline compound found in the brain. It is also available as a dietary supplement. It increases acetylcholine levels, a neurotransmitter significant for memory and learning. Many people use Alpha GPC to enhance cognitive function, improve memory, and boost physical performance.

Alpha GPC is well-tolerated by most people. It is used in Europe as a prescription drug for Alzheimer’s disease and other cognitive disorders. In the U.S., it is available as a dietary supplement. The standard dosage ranges from 200 to 600 milligrams per day, but higher doses are used for specific conditions like Alzheimer’s disease.

Benefits of Alpha GPC

Alpha GPC offers several benefits. It improves cognitive function, memory, and learning. It also enhances physical performance by increasing power output and muscle strength. Athletes use it to boost stamina and reduce recovery time after workouts. Studies show that Alpha GPC increases growth hormone levels, which helps in muscle building and recovery.

Alpha GPC is also used to support brain health in aging individuals. It helps prevent cognitive decline and improves symptoms of Alzheimer’s disease. Some studies suggest that it may also help in stroke recovery by improving cognitive and functional outcomes.

Potential Side Effects

While Alpha GPC is generally safe, it can cause side effects in some people. Common side effects include fatigue, nausea, headaches, upset stomach, diarrhea, heartburn, and nervousness. Some individuals may experience low blood pressure and lightheadedness. High doses can increase the risk of adverse effects, so it is significant to stick to the recommended dosage.

Alpha GPC is derived from soy lecithin, which can cause allergic reactions in some people. Symptoms include nausea, bloating, upset stomach, and skin rashes. Pregnant and nursing women should avoid Alpha GPC due to insufficient research on its safety in these cases.

Alpha GPC and Anxiety

The link between Alpha GPC and anxiety is not well-established. Some users report anxiety as a side effect, but it is not common. According to a study, Alpha GPC did not show significant effects on anxiety in healthy volunteers. However, individual responses to supplements can vary, and some people may experience anxiety.

Alpha GPC increases acetylcholine levels, which can affect mood and anxiety. Acetylcholine is involved in the regulation of the parasympathetic nervous system, which controls the body’s rest and digest functions. An imbalance in acetylcholine levels can lead to anxiety in some individuals.

Risks and Precautions

Alpha GPC is generally safe when used appropriately. However, long-term use and high doses can increase the risk of stroke. A study found that Alpha GPC users had a higher risk of stroke compared to non-users. The risk increased with the duration of use and dosage.

Alpha GPC can also interact with other medications. It increases acetylcholine levels, which can interfere with medications that block acetylcholine, such as scopolamine. It is significant to consult a healthcare provider before starting Alpha GPC, especially if you are taking other medications.


Alpha GPC offers several cognitive and physical benefits, but it can cause side effects in some people. Anxiety is a potential side effect, but it is not common. Most users experience improved cognitive function and physical performance. It is significant to use Alpha GPC as directed and consult a healthcare provider if you experience any adverse effects.


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