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How Ashwagandha Reduces Stress

Ashwagandha reduces stress by modulating the HPA axis, lowering cortisol levels, and influencing neurotransmitters.

Ashwagandha, a key herb in Ayurvedic medicine, has adaptogenic properties that help the body manage stress. This blog explores how ashwagandha reduces stress, supported by scientific research and clinical trials.

Modulating the HPA Axis

The Hypothalamic-Pituitary-Adrenal (HPA) axis is crucial in the body’s stress response. Chronic stress disrupts the HPA axis, leading to elevated cortisol levels. High cortisol can cause anxiety, depression, metabolic disorders, immune dysfunction, cardiovascular disease, and sleep issues. Ashwagandha helps modulate the HPA axis, reducing cortisol levels and mitigating stress responses. According to a study, ashwagandha effectively relieves chronic stress by balancing the HPA axis.

Lowering Cortisol Levels

Cortisol, the “stress hormone”, plays a significant role in stress response. Elevated cortisol levels are linked to increased stress and anxiety. Studies show that ashwagandha supplementation significantly reduces cortisol levels. For example, a study with 60 participants taking 240 mg of ashwagandha extract daily for 60 days showed significant reductions in anxiety and cortisol levels compared to a placebo group (Healthline).

Influencing Neurotransmitters

Ashwagandha affects neurotransmitters like serotonin and gamma-aminobutyric acid (GABA), which regulate mood and anxiety. By enhancing these neurotransmitters’ activity, ashwagandha helps alleviate stress and anxiety symptoms. A study found that participants taking ashwagandha reported improvements in stress, anxiety, and depression scores (NCBI).

Clinical Evidence

Systematic Reviews and Meta-Analyses

A 2021 systematic review identified seven studies on ashwagandha for stress and anxiety. These studies, involving 491 adults from India, found that ashwagandha significantly reduced stress and anxiety levels, improved sleep quality, and lowered serum cortisol levels (NIH). Another meta-analysis of 12 randomized clinical trials with 1,002 participants concluded that ashwagandha supplementation significantly reduced anxiety and stress levels compared to placebo (PubMed).

Randomized Controlled Trials

Several randomized controlled trials (RCTs) support ashwagandha’s efficacy in stress reduction. An eight-week RCT with 58 participants found that those taking 250 mg or 600 mg of ashwagandha extract daily experienced significant reductions in perceived stress and cortisol levels compared to the placebo group (NCBI). Another study in Florida with 60 participants reported positive effects on stress, anxiety, depression, and food cravings after taking 225 mg/day or 400 mg/day of a proprietary ashwagandha extract for 30 days (NIH).

Dose-Response Relationship

Ashwagandha’s effectiveness appears dose-dependent. A study in the journal Nutrients found that doses as low as 125 mg/day of ashwagandha extract reduced stress parameters in chronically stressed subjects. Higher doses, such as 250 mg/day and 500 mg/day, also showed significant stress reduction, with improvements observed in both validated questionnaires and stress-related biomarkers (NutraIngredients).

Safety and Tolerability

Ashwagandha is generally safe for most people when used short-term. Clinical studies report that ashwagandha is well-tolerated, with few adverse effects. However, it may not be suitable for everyone. Pregnant or breastfeeding individuals and those with autoimmune diseases should consult their healthcare provider before using ashwagandha (Cleveland Clinic).

Limitations and Future Research

Current evidence supports ashwagandha for stress reduction, but there are limitations. Many trials have little sample sizes and short durations, affecting the generalizability of results. Studies use various ashwagandha preparations and doses, making it hard to identify specific extracts or recommended amounts. Further high-quality studies with larger cohorts and diverse populations are needed to confirm ashwagandha’s clinical efficacy and establish standardized dosing guidelines (NIH).

Key Takeaways

  • Ashwagandha modulates the HPA axis.
  • It lowers cortisol levels.
  • It influences neurotransmitters.
  • Clinical evidence supports its efficacy.
  • Generally safe with few adverse effects.
  • More research needed for standardized dosing.


Ashwagandha shows promise as a natural, cost-effective, and side-effect-free option for managing stress and anxiety. Its ability to modulate the HPA axis, reduce cortisol levels, and influence neurotransmitters makes it valuable for stress management. While more research is needed for standardized dosing and long-term safety, current evidence suggests ashwagandha can effectively reduce stress and improve overall well-being.